Metarhodopsin-II stabilization by crosslinked Gtα C-terminal peptides and implications for the mechanism of GPCR-G protein coupling
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Metarhodopsin-II stabilization by crosslinked Gtα C-terminal peptides and implications for the mechanism of GPCR-G protein coupling
Metarhodopsin-II is the light-excited form of rhodopsin that triggers G protein function. Metarhodopsin-II is stabilized when the N-terminus of the carboxyl (340-350) tail peptide of the alpha-subunit of transducin (Gtalpha) is crosslinked to rhodopsin cysteine 140 or the 340-350 peptide C-terminus of Gtalpha is crosslinked to rhodopsin cysteine 316. When the N-terminus of the peptide is couple...
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ژورنال
عنوان ژورنال: Vision Research
سال: 2006
ISSN: 0042-6989
DOI: 10.1016/j.visres.2006.08.015